HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile | HCID 22260780 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid | HCID 22260956 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A total of 172 mg of 3-(3-fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile obtained in Production Example II-1-d was dissolved in 2 ml of acetic acid, 0.7 ml of water and 0.5 ml of sulfuric acid, followed by stirring at 110° C. for 18 hours. After cooling to room temperature, water was added to the reaction mixture. The resulting crystals were washed with water, to give 159 mg of the title compound as light pink crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541376B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-dc26b9cb951b4c1a85321b7e33b581b8 |
| Source note | uspto-grants-2009_06 |