反应详情

温度

60 °C

To a solution of 7.0 g of 4-fluoro-3-[(3-fluorophenyl)-hydroxymethyl]-5-methoxybenzonitrile in 70 ml toluene was added 11.1 g of activated manganese dioxide at room temperature. After stirring at 60° C. for one day, the manganese dioxide was filtered off through Celite. The solvent was removed and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:3), to give 640 mg of the title compound as colorless crystals.

1. filtrationthe manganese dioxide was filtered off through Celite
2. customThe solvent was removed
3. customthe crude product was purified
4. customseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:3)