反应详情

To a stirred solution of the product of step 1 (1.08 g, 4.88 mmol) in ethanol (20 mL) was added 10% palladium on activated carbon (0.100 g). The reaction vessel was evacuated and backfilled with nitrogen several times. After a final evacuation the reaction vessel was backfilled with hydrogen. After 3.5 hours the hydrogen atmosphere was removed and the mixture was filtered through Celite and concentrated to afford 0.97 g (100%) of product as an amber gum: 1H NMR (CDCl3) δ 6.93 (d, J=8.6 Hz, 1H), 6.68 (d, J=8.6 Hz, 1H), 3.78 (br s, 2H), 3.20 (s, 3H), 2.04 (t, J=7.3 Hz, 2H 1.63-1.52 (m, 2H), 0.82 (t, J=7.4 Hz, 3H) ppm.

1. customThe reaction vessel was evacuated
2. customAfter 3.5 hours the hydrogen atmosphere was removed
3. filtrationthe mixture was filtered through Celite
4. concentrationconcentrated