Hydrochloric Acid → HCID 66757799, compound

Participants

Reaction Steps

A solution of the compound of Example 420 (91 mg, 0.14 mmol) in MeOH (5 mL) was treated with a 0.4 M solution of lithium hydroxide (5 ml, 2 mmol) and stirred for 3 hours. After addition of 5 ml of 0.4 N HCl, the solvent was removed under reduced pressure to give the crude product. The residue was purified using silica gel chromatography eluting with a dichloromethane:methanol gradient (0 to 50% MeOH over 1 hour) to give the title compound (48 mg).

Provenance & Evidence