Trifluoroacetic acid → HCID 22058310, compound

Participants

Reaction Conditions

Reaction Steps

The product of step 2 (500 mg, 1.37 mmol) was dissolved in methylene chloride (10 ml) and the resulting solution cooled to 0° C. Trifluoroacetic acid (3 ml) was slowly added and the reaction was allowed to stir at 0° C. for 2 h, before concentration under reduced pressure. The trifluoroacetate salt was dissolved in tetrahydrofuran and excess triethylamine was added. Solids generated were removed by suction filtration and the supernatant solution was concentrated to afford 4-(4-chloro-phenyl)-piperidine-3,4-diol.

Provenance & Evidence