Water → HCID 54752976, compound

Participants

Reaction Conditions

Reaction Steps

DBU (211 ml) was added to a solution of (3-bromophenyl) (4-chloro-2-hydroxy-5-methylphenyl)methanone (170 g) in acetonitrile (510 ml) at 25 to 30° C. Then, a solution of ethyl succinic chloride (146 g) in acetonitrile (340 ml) was added dropwise over 30 minutes at 25 to 40° C. After the drop was completed, the mixture was stirred at 30° C. for 1 hour. Water (94 ml) was added dropwise keeping the reaction solution at 25 to 30° C. After the mixture was stirred at the same temperature for 1 hour, the resulting crystals were filtered, and washed with a mixture of acetonitrile and water (9/1, 170 ml) four times, dried under reduced pressure to obtain the title compound (174 g, yield 76.7%).

Provenance & Evidence