Sodium Hydroxide → HCID 57713317, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}acrylic acid acetone solvate (1.13 g) and acetone (20.5 ml) was heated to 50° C., and 2N NaOH (0.91 ml) was added dropwise thereto with stirring. The mixture was stirred at 50° C. for 2 hours and then at 5° C. for 1 hour, and crystals precipitated were collected by filtration. The crystals were washed successively with cold acetone/water (95/5, 2 ml) and cold acetone (2 ml) to obtain the title compound (0.974 g, yield 91.9%).

Provenance & Evidence