Ammonia → HCID 86614658, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}acrylic acid acetone solvate (6.18 g), ethanol (56 ml) and water (11 ml) was heated to 60° C., and 5% aqueous ammonia (6 ml) was added dropwise thereto with stirring to dissolve the mixture. The solution was concentrated under reduced pressure and crystals obtained were dried at 45° C. for 8 hours under reduced pressure to obtain the title compound as colorless crystals (5.20 g, yield 90.1%).

Provenance & Evidence