Ethanol → HCID 87605692, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}acrylic acid (10.0 g), tris(hydroxymethyl)methylamine (2.2 g), ethanol (70 ml) and acetonitrile (100 ml) was heated and stirred at 70° C. to dissolve the mixture. Acetonitrile (200 ml) was slowly added to the reaction mixture, and the mixture was stirred at 70° C. for 3 hours, gradually cooled to room temperature, and then stirred at room temperature overnight. Crystals obtained were collected by filtration, washed with acetonitrile, and dried at 60° C. for 8 hours under reduced pressure to obtain the title compound as colorless crystals (10.5 g, yield 86%). The crystals obtained showed the X-ray powder diffraction pattern as shown in FIG. 3 and crystallinity was 64%.

Provenance & Evidence