HCID 57713360, compound → HCID 12371552, compound

HRID 1983873Notes

Reaction equation

HRID 1983873 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)=[N+]=[N-]>ClC1C=CC=CC=1Cl>[S:11]1[C:10]2[C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[NH:1][C:14]=2[CH:13]=[CH:12]1

Participants

3

Reactant 1

HCID 57713360HCID 57713360, compound

Product 1

HCID 12371552HCID 12371552, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Conditions

Temperature
180 °C

Procedure

5.0 g of 2-(2′-azido-phenyl)-thiophene (B′) was dissolved in 100 ml of ortho-dichlorobenzene and the solution was refluxed at 180° C. for 12 hours. After the reaction was completed, the resulting solution was dried and purified by column chromatography using toluene. Finally, 3.12 g (yield: 77%) of 4H-thieno[3,2-b]indole (C′) was obtained.

Workup

  1. customthe resulting solution was dried
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-68fec947a671464eaf0edf2b2a0630da
Source dataset
uspto-grants-2009_06
Patent number
US07541736B2

Reaction notes

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