Methyl 5-aminobenzofuran-2-carboxylate → N4-(3,4-dichlorophenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine

HRID 198393Notes

Reaction equation

HRID 198393 reaction equation
[Cl:15][c:16]1[n:17][cH:18][c:19]([F:31])[c:20]([NH:22][c:23]2[cH:24][c:25]([Cl:30])[c:26]([Cl:29])[cH:27][cH:28]2)[n:21]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:10](=[O:11])[O:12][CH3:13])[o:9]2)[cH:14]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:10](=[O:11])[O:12][CH3:13])[o:9]2)[cH:14]1)[c:16]1[n:17][cH:18][c:19]([F:31])[c:20]([NH:22][c:23]2[cH:24][c:25]([Cl:30])[c:26]([Cl:29])[cH:27][cH:28]2)[n:21]1

Participants

3

Reactant 2

HCID 10845388Methyl 5-aminobenzofuran-2-carboxylateHCID 22060411(2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine

Product 1

HCID 22060299N4-(3,4-dichlorophenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-114c49e1e4494066b1e6701e83e76fef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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