Acetic Anhydride → HCID 178505439, compound

Participants

Reaction Conditions

Reaction Steps

Propanediol (0.3 mole) is cooled under a nitrogen atmosphere to a temperature of 0° C. Then 4-bromo-3,5-difluorophenylbenzoylchloride (0.3 mole) are swiftly added with continuous stirring. The reaction mixture is then cooled to −10° C. and triflic acid (0.45 mole) is added. The reaction mixture is stirred further for 1 hour, then acetic anhydride (2 mole) is added maintaining the temperature below 5° C. After adding diethyl ether and stirring for 1 more hour at −10° C., 4-bromo-3,5-difluorophenyl-thianylium triflate is filtered off and washed with cold ether.

Provenance & Evidence