Water → 2-Fluoro-6-methoxybenzonitrile

Participants

Reaction Conditions

Reaction Steps

640.5 g (4.6 mol) of difluorobenzonitrile were dissolved in 3.5 l of methanol and then cooled to 0-5° C. 828.8 g of 30% strength sodium methoxide solution were added dropwise in this temperature range, and the reaction mixture was stirred at room temperature overnight. Then the reaction mixture was added to 20 l of water and the precipitate was filtered off with suction and washed twice with water and twice with heptane. The solid was dried in vacuo at 50° C. Yield: 740 g (99% of theory) of a white solid with a purity of >95% according to GC. 1H NMR (in CDCl3): δ=3.95 ppm (s, 3H, O—CH3), 6.85 ppm (m, 2H, arom. H), 7.5 ppm (q, 1H, arom. H).

Provenance & Evidence