HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butanoic acid, 4-chloro-4-oxo-, methyl ester → 4-(3,4-Diethoxy-phenyl)-4-oxo-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butanoic acid, 4-chloro-4-oxo-, methyl ester | HCID 73888 | — |
| Reactant | o-Diethoxybenzene | HCID 74904 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3,4-Diethoxy-phenyl)-4-oxo-butyric acid methyl ester | HCID 57714098 | — |
Reaction Steps
1.1 A solution of 70 ml 3-chlorocarbonyl-propionic acid methyl ester in 100 ml dichloromethane is added to a suspension of 80.0 g of AlCl3 in 300 ml dichloromethane at 20-25°. At 0° a solution of 85.0 g 1,2-diethoxybenzene in 100 ml dichloromethane is added. The solution is tirred for 14 hours at room temperature. Work-up is as usual, yielding 122.2 g of 4-(3,4-diethoxy-phenyl)-4-oxo-butyric acid methyl ester (“AA”), m.p. 84-85°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544684B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-775459e4bbda44d7874e9c00b11fe8a0 |
| Source note | uspto-grants-2009_06 |