Diisopropylethylamine → HCID 178520989, compound

Participants

Reaction Steps

A mixture of 214 mg (1.5 mmol) of cis-4-hydroxycyclohexanecarboxylic acid (commercially available), 316 mg (1.5 mmol) of 1-(2-cyclobutyl)-piperazine dihydrogen chloride (WO 2004101546), 572 mg (1.8 mmol) of TBTU and 751 mg (7.4 mmol) of DIPEA in 5 ml DMF was stirred for 8 h at room temperature. The mixture was diluted with ethyl acetate, washed with water and brine, and evaporated. The residue was purified by column chromatography on silica eluting with CH2Cl2 and methanol=9:1. Evaporation of the combined product fractions yielded 300 mg (76%) of the title compound as light brown oil. MS (m/e): 267.1 (MH+).

Provenance & Evidence