Triethylamine → HCID 178520990, compound

Participants

Reaction Steps

A mixture of 500 mg (3.5 mmol) of cis-4-hydroxycyclohexanecarboxylic acid (commercially available), 739 mg (3.5 mmol) of 1-(2-cyclobutyl)-piperazine dihydrogen chloride (WO 2004101546), 1.23 g (3.8 mmol) of TBTU and 1.40 g (13.8 mmol) of triethylamine in 7 ml DMF was stirred for 12 h at room temperature. The mixture was diluted with ethyl acetate, washed with water and brine, and evaporated. The residue was purified by column chromatography on NH2-silica gel eluting with CH2Cl2 and methanol=from 100:0 to 98:2. Evaporation of the combined product fractions yielded 600 mg (65%) of the title compound as light brown oil. MS (m/e): 267.1 (MH+).

Provenance & Evidence