2-Chloro-5-hydroxypyridine → HCID 178520983, compound

HRID 1984018Notes

Reaction equation

HRID 1984018 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8]([C:11]([C@H:13]3[CH2:18][CH2:17][C@H:16]([OH:19])[CH2:15][CH2:14]3)=[O:12])[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24](O)=[CH:23][N:22]=1>>[Cl:20][C:21]1[N:22]=[CH:23][C:24]([O:19][C@@H:16]2[CH2:17][CH2:18][C@H:13]([C:11]([N:8]3[CH2:9][CH2:10][N:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)[CH2:6][CH2:7]3)=[O:12])[CH2:14][CH2:15]2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 8198212-Chloro-5-hydroxypyridineHCID 178520990HCID 178520990, compound

Product 1

HCID 178520983HCID 178520983, compound

Procedure

According to the procedure described for example 1, the title compound had been synthesized from trans-(4-cyclobutyl-piperazin-1-yl)-(4-hydroxy-cyclohexyl)-methanone and 2-chloro-5-hydroxypyridine. MS (m/e): 378.3 (MH+).

Sources & evidence

ORD record
ord-0e67481ec1194bcaba9f36f36292d61f
Source dataset
uspto-grants-2009_06
Patent number
US07544683B2

Reaction notes

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