HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178456387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178525779 | HCID 178525779 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178456387 | HCID 178456387 | 120.6% |
Reaction Steps
A mixture of 428 mg (3.0 mmol) of cis-4-hydroxycyclohexanecarboxylic acid (commercially available), 318 mg (1.5 mmol) of 1-(isopropyl)-piperazine (commercially available), 1.14 g (3.6 mmol) of TBTU and 900 mg (9 mmol) of triethylamine in 3 ml DMF was stirred for 12 h at room temperature. The mixture was purified by column chromatography on silica eluting with CH2Cl2 and methanol=9:1. Evaporation of the combined product fractions yielded 460 mg (61%) of the title compound as light brown oil. MS (m/e): 255.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544683B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-65e1c6c36ddc44a5b92ed7e47adf12f5 |
| Source note | uspto-grants-2009_06 |