Triethylamine → HCID 178456388, compound

Participants

Reaction Steps

A mixture of 1 g (6.9 mmol) of trans-4-hydroxycyclohexanecarboxylic acid (commercially available), 1.07 mg (8.3 mmol) of 1-(isopropyl)-piperazine (commercially available), 2.67 g (8.3 mmol) of TBTU and 1.54 g (15.2 mmol) of triethylamine in 7 ml DMF was stirred for 12 h at room temperature. The mixture was diluted with AcOEt, washed with water and brine, dried over MgSO4, and evaporated. The mixture was purified by column chromatography on NH2-silicagel eluting with CH2Cl2 and methanol=from 100:0 to 98:2. Evaporation of the combined product fractions yielded 0.9 g (51%) of the title compound as brown oil. MS (m/e): 255.2 (MH+).

Provenance & Evidence