Trimethyl orthoacetate → HCID 178433957, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 mg (0.26 mmol) of trans-4-[4-(4-Isopropyl-piperazine-1-carbonyl)-cyclohexyloxy]-benzoic acid hydrazide and 4 ml of trimethyl orthoacetate was stirred for 10 min at 120° C. using microwave reactor. After evaporation, the mixture was diluted with AcOEt, washed with saturated NaHCO3 solution, water and brine, dried over Na2SO4, and evaporated. The residue was purified by column chromatography on silica eluting with dichloromethane and methanol=from 98:2 to 19:1. The combined product fractions were evaporated to dryness to yield 15 mg (14%) of the title compound. MS (m/e): 413.4 (MH+).

Provenance & Evidence