Sodium Hydroxide → HCID 178456377, compound

Participants

Reaction Steps

A mixture of 80 mg (0.21 mmol) of trans-4-[4-(4-Isopropyl-piperazine-1-carbonyl)-cyclohexyloxy]-benzoic acid hydrazide, 0.02 ml (0.26 mmol) of cyclopropanecarboxylic acid and 2 ml of phosphorus oxychloride was refluxed for 2 hr. To the mixture, 1N NaOH solution was added. The mixture was extracted with AcOEt, washed with saturated NaHCO3 solution, dried over Na2SO4, and evaporated. The residue was purified by column chromatography on silica eluting with dichloromethane and methanol=from 98:2 to 19:1. The combined product fractions were evaporated to dryness to yield 56 mg (56%) of the title compound. MS (m/e): 439.4 (MH+).

Provenance & Evidence