4-Cyanophenol → HCID 178456380, compound

Participants

Reaction Steps

To a mixture of 1.0 g (3.93 mmol) of cis-(4-isopropyl-piperazin-1-yl)-(4-hydroxy-cyclohexyl)-methanone, 0.515 g (4.3 mmol) of 4-cyanophenol, 1.28 g (4.88 mmol) of triphenylphisphine in 6 ml THF, 1.11 g (4.82 mmol) of di-tert-butyl azodicarboxylate in 6 ml of THF was added at 0° C., and stirred for 72 hr at room temperature. After evaporation, the residue was purified by column chromatography on silica gel eluting with cyclohexane and ethyl acetate=from 1:1 to 1:3, then dichloromethane and methanol=19:1. The combined product fractions were evaporated to dryness to yield 0.26 g (19% yields) of the titled compound. MS (m/e): 356.2 (MH+).

Provenance & Evidence