Morpholine → 4-Bromo-3-(morpholine-4-sulfonyl)benzoic acid

Participants

Reaction Steps

4-Bromo-3-chlorosulfonyl-benzoic acid (2.2, 1.1 g) was dissolved in 20 mL of ethyl acetate and morpholine (Aa, 1.48 mL, 3 eq) was added. The mixture was stirred at room temperature for 2 hours, then extracted with 15 mL of 0.5M HCl. The organic layer was washed with H2O and brine and the solvent evaporated to yield 4-bromo-3-(morpholinosulfonyl)-benzoic acid (2.3.Aa) as an off-white powder (1.13 mg, 88% yield). MS analysis (m−1)=348.

Provenance & Evidence