Methanol → HCID 68853836, compound

Participants

Reaction Conditions

Reaction Steps

Into a 5 mL microwave flask 4-bromo-3-(morpholinosulfonyl)-N-((1S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)benzamide (2.4.AaBa, 0.3 g, 0.6 mmol) was dissolved in methanol (2 mL, 0.05 mol). Bis(dibenzylideneacetone)palladium(0) (0.02 g, 0.03 mmol), (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.02 g, 0.03 mmol), and potassium tert-butoxide (0.5 mL, 4 mmol) were then added. The reaction was heated in the microwave oven at 140° C. for 1 h. The solvent was evaporated and prep-HPLC was performed to yield product 2K in 20% yield as a white, crystalline solid. MS analysis (m+1)=437.6.

Provenance & Evidence