HCID 57713860, compound → HCID 11950887, compound

HRID 1984067Notes

Reaction equation

HRID 1984067 reaction equation
[Cl:1][C:2]1[C:3]2[C:17]([C:18]#[C:19][CH2:20][N:21]([CH:25]([CH3:27])[CH3:26])[CH:22]([CH3:24])[CH3:23])=[CH:16][N:15]([CH2:28][C:29]3[C:34]([CH3:35])=[C:33]([O:36][CH3:37])[C:32]([CH3:38])=[CH:31][N:30]=3)[C:4]=2[N:5]=[C:6]([NH:8]C(=O)C(C)(C)C)[N:7]=1>[Cl-].[Cl-].[Zn+2]>[Cl:1][C:2]1[C:3]2[C:17]([C:18]#[C:19][CH2:20][N:21]([CH:22]([CH3:24])[CH3:23])[CH:25]([CH3:27])[CH3:26])=[CH:16][N:15]([CH2:28][C:29]3[C:34]([CH3:35])=[C:33]([O:36][CH3:37])[C:32]([CH3:38])=[CH:31][N:30]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 1

HCID 57713860HCID 57713860, compound

Product 1

HCID 11950887HCID 11950887, compound

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

The title compound was prepared by cleaving the pivaloyl protecting group of N-[4-chloro-5-(3-diisopropylamino-prop-1-ynyl)-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide with ZnCl2 according to the General Procedure B. tR: 4.71 min. 1H-NMR (CDCl3) δ 8.24 (s, 1H), 7.05 (s, 1H), 5.30 (s, 2H), 4.96 (s, 1H), 3.76 (s, 3H), 3.68 (s, 2H), 3.27 (7, 2H), 2.27 (s, 2H), 2.20 (s, 2H), 1.15 (d, 12H).

Sources & evidence

ORD record
ord-11192db9732548819576a4f879452f99
Source dataset
uspto-grants-2009_06
Patent number
US07544672B2

Reaction notes

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