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HRID1984071

反应详情

EQUATION

反应方程式

HRID 1984071 的结构方程式

REACTANTS

反应物

1
结构：COc1c(C)cnc(Cn2cc(C#C[Si](C)(C)C)c3c(Cl)nc(NC(=O)C(C)(C)C)nc32)c1C
HCID57713844

未命名化合物

PRODUCTS

生成物

1
结构：COc1c(C)cnc(Cn2cc(C#C[Si](C)(C)C)c3c(Cl)nc(N)nc32)c1C
HCID57713858

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cl-].[Cl-].[Zn+2]
催化剂HCID3007855

Zinc chloride

Cl2Zn

PROCEDURE

实验过程

The title compound was prepared by cleaving the pivaloyl protecting group of N-[4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-trimethylsilanylethynyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide with ZnCl2 according to the General Procedure B. tR=6.56 min. 1H NMR (CDCl3) δ 8.22 (s, 1H), 7.11 (s, 1H), 5.30 (s, 2H), 5.09 (s, 2H), 3.75 (s, 3H), 2.26 (s, 3H), 2.18 (s, 3H), 0.24 (s, 9H).