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HRID1984085

反应详情

EQUATION

反应方程式

HRID 1984085 的结构方程式

REACTANTS

反应物

2
结构：C#CCC(C)(C)O
HCID234735

2-methylpent-4-yn-2-ol

C6H10O

结构：COc1c(C)cnc(Cn2cc(I)c3c(Cl)nc(N)nc32)c1C
HCID44228964

4-Chloro-5-iodo-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

C15H15ClIN5O

PRODUCTS

生成物

1
结构：COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc32)c1C
HCID11517212

5-{2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methyl-4-pentyn-2-ol

C21H24ClN5O2

PROCEDURE

实验过程

Sonogashira coupling of 4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine with 2-methylpent-4-yn-2-ol (H. Zhang et al., Tetrahedron Lett. 1999, 40, 7851) according to the general procedure A gave the title compound, as a solid. Mp=163-165° C. HPLC Rt=4.98 min.