HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 1-Pent-4-ynylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pent-4-yn-1-yl methanesulfonate | HCID 12476209 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-Pent-4-ynylimidazole | HCID 13865366 | 53.8% |
Reaction Steps
A mixure of pent-4-ynyl methanesulfonate (1.06 g), imidazole (534 mg) and K2CO3 (3.66 g) in 2-butanone (11 mL) was heated to reflux overnight. Work-up (DCM, H2O), drying (Na2SO4) and concentration gave 1-(pent-4-ynyl)-1H-imidazole (472 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544672B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-20d2c9679d214986a1a8419e960c9de1 |
| Source note | uspto-grants-2009_06 |