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HRID1984115

反应详情

EQUATION

反应方程式

HRID 1984115 的结构方程式

REACTANTS

反应物

3
结构：CC[C@@H]1CN2CC[C@@H]1C[C@@H]2[C@H](Oc1nnc(O[C@H](c2ccnc3ccc(OC)cc23)[C@H]2C[C@@H]3CCN2C[C@@H]3CC)c2ccccc12)c1ccnc2ccc(OC)cc12
HCID51003674

(3alpha)-6'-Methoxy-9-[(4-{[(4beta)-6'-methoxy-10,11-dihydrocinchonan-9-yl]oxy}phthalazin-1-yl)oxy]-10,11-dihydrocinchonan

C48H54N6O4

结构：C=C(C)C#Cc1cn(Cc2ncc(C)c(OC)c2C)c2nc(N)nc(Cl)c12
HCID57713816

未命名化合物

结构：CC(C)(C)O.O
HCID71401949

2-Methylpropan-2-ol--water (1/1)

C4H12O2

PRODUCTS

生成物

1
结构：COc1c(C)cnc(Cn2cc(C#C[C@](C)(O)CO)c3c(Cl)nc(N)nc32)c1C
HCID57713819

未命名化合物

PROCEDURE

实验过程

Treatment of 4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-(3-methylbut-3-en-1-ynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine (see example 51) (263 mg) with AD-mix-α (Aldrich, 1.41 g) in t-BuOH:water 1:1: (7 mL) at rt for 3 days, followed by quench (NaHSO3, 1.6 g), work-up, and preparative HPLC gave the title compound (69 mg), as a solid. HPLC Rt=4.36 min

WORKUP

后处理

  1. customby quench (NaHSO3, 1.6 g)