Sodium Hydroxide → 2-(5-Methyl-2-phenyl-4-oxazolyl)ethanol

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Reaction Steps

2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)-acetic acid methyl ester (2.3 g, 10 mmol) was dissolved in 16 mL of Et2O, and then added dropwise at 0° C. to a suspension of LiAlH4 (0.38 g, 10 mmol) in Et2O (4 mL). The solution was stirred at room temperature overnight, to which 0.4 mL H2O, 0.4 mL of 15% NaOH solution, and 1.2 mL of H2O, and a spoon of anhydrous MgSO4 were carefully added in turn. The mixture was filtered, and the filtrate was concentrated to give 1.6 g of 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethanol as a light yellow solid with a yield of 80%.

Provenance & Evidence