N-Phenyl diethanolamine → (S)-3-(3-bromo-4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(4-phenylpiperazin-1-yl)propanoic acid

Participants

Reaction Steps

Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 2,2′-(phenylazanediyl)diethanol was used in place of 2,2′-(m-tolylazanediyl)diethanol to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-2-(4-phenylpiperazin-1-yl)-propanoic acid as a white solid with the yield of 30% and mp of 220-222° C.

Provenance & Evidence