HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1984125Generated: November 3, 2026
1-Phenylpiperazine → 2-[2-(4-phenylpiperazin-1-yl)ethyl]isoindole-1,3-dione
https://huagongshe.com/reaction/1984125
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[2-(4-phenylpiperazin-1-yl)ethyl]isoindole-1,3-dione | HCID 8597984 | 55.6% |
Reaction Steps
4-phenylpiperazine (4.50 g, 27.74 mmol) was dissolved in 30 ml DMF, then K2CO3 (11.50 g, 83.21 mmol) and N-(2-bromoethyl)phthalimide (8.46 g, 33.28 mmol) were added thereto and stirred at about 80° C. The reaction progress and completion were confirmed using TLC (hexane:EtOAc=1:1). Upon completion of the reaction, water was added to the reaction mixture and then was extracted with CH2Cl2. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The concentrate was separated by column chromatography (hexane:EtOAc:CH2Cl2=3:1:2) to obtain the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07544686B2 |
|---|
| Source dataset | uspto-grants-2009_06 |
|---|
| ORD ID | ord-aadba0a2ee324c9e90d36da4cbef783b |
|---|
| Source note | uspto-grants-2009_06 |
|---|
