2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 1-t-Butyl-5-propyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984129Notes

Reaction equation

HRID 1984129 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([C:19]1[N:23]([C:24]([CH3:27])([CH3:26])[CH3:25])[N:22]=[C:21]([CH:28]=O)[CH:20]=1)[CH2:17][CH3:18]>>[C:24]([N:23]1[C:19]([CH2:16][CH2:17][CH3:18])=[CH:20][C:21]([CH2:28][NH:15][CH2:14][CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:12][CH2:11]2)=[N:22]1)([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 862610955-Propyl-1-t-butylpyrazole-3-carbaldehyde

Product 1

HCID 160393951-t-Butyl-5-propyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 64.2%

Procedure

Compound 3 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 5-propyl-1-t-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-a3696f00d25c4c8588349ade6d47e845
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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