2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 1-t-Butyl-5-iso-butyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984131Notes

Reaction equation

HRID 1984131 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]([N:20]1[C:24]([CH2:25][CH:26]([CH3:28])[CH3:27])=[CH:23][C:22]([CH:29]=O)=[N:21]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([N:20]1[C:24]([CH2:25][CH:26]([CH3:27])[CH3:28])=[CH:23][C:22]([CH2:29][NH:15][CH2:14][CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:12][CH2:11]2)=[N:21]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 224935831-Tert-butyl-5-iso-butyl-3-formylpyrazole

Product 1

HCID 160393961-t-Butyl-5-iso-butyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 25.8%

Procedure

Compound 5 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 1-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-a24bde52be4a4980b552c5cf3563c63d
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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