2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 2-t-Butyl-5-isobutyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984132Notes

Reaction equation

HRID 1984132 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]([N:20]1[C:24]([CH:25]=O)=[CH:23][C:22]([CH2:27][CH:28]([CH3:30])[CH3:29])=[N:21]1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([N:20]1[C:24]([CH2:25][NH:15][CH2:14][CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:12][CH2:11]2)=[CH:23][C:22]([CH2:27][CH:28]([CH3:30])[CH3:29])=[N:21]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 866110582-t-Butyl-5-iso-butylpyrazole-3-carbaldehyde

Product 1

HCID 160394662-t-Butyl-5-isobutyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 50.1%

Procedure

Compound 6 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 2-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-9ed3fc34d6b047f49831dca14448a20c
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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