2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 5-Iso-butyl-1-phenyl-3-[2-(4-phenyl piperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984133Notes

Reaction equation

HRID 1984133 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([C:20]1[N:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:23]=[C:22]([CH:31]=O)[CH:21]=1)[CH:17]([CH3:19])[CH3:18]>>[CH2:16]([C:20]1[N:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:23]=[C:22]([CH2:31][NH:15][CH2:14][CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:12][CH2:11]2)[CH:21]=1)[CH:17]([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 592816115-Isobutyl-1-phenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160394675-Iso-butyl-1-phenyl-3-[2-(4-phenyl piperazin-1-yl)ethyl]aminomethylpyrazoleYield 56.2%

Procedure

Compound 7 was prepared using the same method as used in Example 1 except that 4-phenylpiperazin-1-ylethylamine and 5-iso-butyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-4743e6c45f68474a880c25566b9774ee
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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