2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 5-(Furan-2-yl)-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984134Notes

Reaction equation

HRID 1984134 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]1([N:22]2[C:26]([C:27]3[O:28][CH:29]=[CH:30][CH:31]=3)=[CH:25][C:24]([CH:32]=O)=[N:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[O:28]1[CH:29]=[CH:30][CH:31]=[C:27]1[C:26]1[N:22]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:23]=[C:24]([CH2:32][NH:15][CH2:14][CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:12][CH2:11]2)[CH:25]=1

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 592816101-Phenyl-5-(2-furyl)pyrazole-3-carbaldehyde

Product 1

HCID 160394685-(Furan-2-yl)-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 69.2%

Procedure

Compound 8 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 1-phenyl-5-(2-furyl)pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-75eac49f6519457ca5a48c7d5ef115fc
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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