2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 1,5-Diphenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984135Notes

Reaction equation

HRID 1984135 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]1([N:22]2[C:26]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:25][C:24]([CH:33]=O)=[N:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:16]1([N:22]2[C:26]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:25][C:24]([CH2:33][NH:15][CH2:14][CH2:13][N:10]3[CH2:9][CH2:8][N:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH2:12][CH2:11]3)=[N:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 534070841,5-Diphenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160394691,5-Diphenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 78.8%

Procedure

Compound 9 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 1,5-diphenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-9ec33511b1824a05a6b98fb0b8b5fb84
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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