2-(4-Phenylpiperazin-1-yl)ethan-1-amine → 5-(4-Cyclohexylphenyl)-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole

HRID 1984138Notes

Reaction equation

HRID 1984138 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:16]1([C:22]2[CH:27]=[CH:26][C:25]([C:28]3[N:32]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[N:31]=[C:30]([CH:39]=O)[CH:29]=3)=[CH:24][CH:23]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([C:22]2[CH:27]=[CH:26][C:25]([C:28]3[N:32]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[N:31]=[C:30]([CH2:39][NH:15][CH2:14][CH2:13][N:10]4[CH2:9][CH2:8][N:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[CH2:12][CH2:11]4)[CH:29]=3)=[CH:24][CH:23]=2)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 47425032-(4-Phenylpiperazin-1-yl)ethan-1-amineHCID 862611315-(4-Cyclohexylphenyl)-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160394725-(4-Cyclohexylphenyl)-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazoleYield 71.2%

Procedure

Compound 12 was prepared using the same method as that of Example 1 except that 4-phenylpiperazin-1-ylethylamine and 5-(4-cyclohexylphenyl)-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-7d17052803404d7c9141e0af8a4bc667
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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