2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamine → 1-t-Butyl-3-{2-[4-(2,3-dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazole

HRID 1984140Notes

Reaction equation

HRID 1984140 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[CH2:18]([C:21]1[N:25]([C:26]([CH3:29])([CH3:28])[CH3:27])[N:24]=[C:23]([CH:30]=O)[CH:22]=1)[CH2:19][CH3:20]>>[C:26]([N:25]1[C:21]([CH2:18][CH2:19][CH3:20])=[CH:22][C:23]([CH2:30][NH:17][CH2:16][CH2:15][N:12]2[CH2:11][CH2:10][N:9]([C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=3[CH3:1])[CH2:14][CH2:13]2)=[N:24]1)([CH3:29])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 45214532-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamineHCID 862610955-Propyl-1-t-butylpyrazole-3-carbaldehyde

Product 1

HCID 160395331-t-Butyl-3-{2-[4-(2,3-dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazoleYield 90.7%

Procedure

Compound 15 was prepared using the same method as that of Example 1 except that 4-(2,3-dimethylphenyl)piperazin-1-ylethylamine and 5-propyl-1-t-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-98bb65d6af544a04bb15980148c44b98
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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