2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamine → 5-Iso-butyl-3-{2-[4-(2,3-dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazole

HRID 1984143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984143
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[CH2:18]([C:22]1[N:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:25]=[C:24]([CH:33]=O)[CH:23]=1)[CH:19]([CH3:21])[CH3:20]>>[CH2:18]([C:22]1[N:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:25]=[C:24]([CH2:33][NH:17][CH2:16][CH2:15][N:12]2[CH2:11][CH2:10][N:9]([C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=3[CH3:1])[CH2:14][CH2:13]2)[CH:23]=1)[CH:19]([CH3:21])[CH3:20]

Komponenten

3

Edukt 2

HCID 45214532-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamineHCID 592816115-Isobutyl-1-phenyl-1H-pyrazole-3-carbaldehyde

Produkt 1

HCID 160384315-Iso-butyl-3-{2-[4-(2,3-dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazoleAusbeute 96,5 %

Versuchsvorschrift

Compound 18 was prepared using the same method as that of Example 1 except that 4-(2,3-dimethylphenyl)piperazin-1-ylethylamine and 5-iso-butyl-1-phenylpyrazole-3-carbaldehyde were used.

Quellen und Nachweise

ORD-Eintrag
ord-6985e5a1be9c4934be99f6a4c85baf19
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544686B2

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