2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(2,3-Dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-1,5-diphenylpyrazole

HRID 1984145Notes

Reaction equation

HRID 1984145 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[C:18]1([N:24]2[C:28]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:27][C:26]([CH:35]=O)=[N:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][NH:17][CH2:35][C:26]2[CH:27]=[C:28]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:25]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 45214532-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethanamineHCID 534070841,5-Diphenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160384333-{2-[4-(2,3-Dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-1,5-diphenylpyrazoleYield 72.9%

Procedure

Compound 20 was prepared using the same method as that of Example 1 except that 4-(2,3-dimethylphenyl)piperazin-1-ylethylamine and 1,5-diphenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-dd564cd9e0ea41dbb315e05fd4433212
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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