4-(2,4-Dimethylphenyl)piperazin-1-ylethylamine → 3-{2-[4-(2,4-Dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-5-methyl-1-phenylpyrazole

HRID 1984147Notes

Reaction equation

HRID 1984147 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[CH3:18][C:19]1[N:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:22]=[C:21]([CH:30]=O)[CH:20]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][CH2:30][C:21]2[CH:20]=[C:19]([CH3:18])[N:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:22]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 47424664-(2,4-Dimethylphenyl)piperazin-1-ylethylamineHCID 141352365-Methyl-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160384963-{2-[4-(2,4-Dimethyl phenyl)piperazin-1-yl]ethyl}aminomethyl-5-methyl-1-phenylpyrazoleYield 39.3%

Procedure

Compound 25 was prepared using the same method as that of Example 1 except that 4-(2,4-dimethylphenyl)piperazin-1-ylethylamine and 5-methyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-226c1b961a884cd7a40f9220a2e315df
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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