4-(2,4-Dimethylphenyl)piperazin-1-ylethylamine → 3-{2-[4-(2,4-Dimethylphenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl-5-propylpyrazole

HRID 1984148Notes

Reaction equation

HRID 1984148 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[CH2:18]([C:21]1[N:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:24]=[C:23]([CH:32]=O)[CH:22]=1)[CH2:19][CH3:20]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][CH2:32][C:23]2[CH:22]=[C:21]([CH2:18][CH2:19][CH3:20])[N:25]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:24]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 47424664-(2,4-Dimethylphenyl)piperazin-1-ylethylamineHCID 862610985-Propyl-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160384983-{2-[4-(2,4-Dimethylphenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl-5-propylpyrazoleYield 73.6%

Procedure

Compound 27 was prepared using the same method as that of Example 1 except that 4-(2,4-dimethylphenyl)piperazin-1-ylethylamine and 5-propyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-4e506440678f42d7bc109e37013a2320
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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