4-(2,4-Dimethylphenyl)piperazin-1-ylethylamine → 1-t-Butyl-5-iso-butyl-3-{2-[4-(2,4-dimethylphenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984149Notes

Reaction equation

HRID 1984149 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]1.[C:18]([N:22]1[C:26]([CH2:27][CH:28]([CH3:30])[CH3:29])=[CH:25][C:24]([CH:31]=O)=[N:23]1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([N:22]1[C:26]([CH2:27][CH:28]([CH3:29])[CH3:30])=[CH:25][C:24]([CH2:31][NH:17][CH2:16][CH2:15][N:12]2[CH2:13][CH2:14][N:9]([C:3]3[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=3[CH3:1])[CH2:10][CH2:11]2)=[N:23]1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 47424664-(2,4-Dimethylphenyl)piperazin-1-ylethylamineHCID 224935831-Tert-butyl-5-iso-butyl-3-formylpyrazole

Product 1

HCID 160384991-t-Butyl-5-iso-butyl-3-{2-[4-(2,4-dimethylphenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 98.7%

Procedure

Compound 28 was prepared using the same method as that of Example 1 except that 4-(2,4-dimethylphenyl)piperazin-1-ylethylamine and 1-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-ac3f5b86399942cfa99da8fbae7501b1
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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