2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazole

HRID 1984155Notes

Reaction equation

HRID 1984155 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[CH3:18][C:19]1[NH:23][N:22]=[C:21]([CH:24]=O)[CH:20]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][NH:17][CH2:24][C:21]3[CH:20]=[C:19]([CH3:18])[NH:23][N:22]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 12561082-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamineHCID 45602443-methyl-1H-pyrazole-5-carbaldehyde

Product 1

HCID 160386363-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazoleYield 30.1%

Procedure

Compound 36 was prepared using the same method as that of Example 1 except that 4-(4-methoxyphenyl)piperazin-1-ylethylamine and 5-methylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-3dfb1a1d37bd46db96fcb8c2b9319fd1
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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