2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamine → 2-t-Butyl-5-iso-butyl-3-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984160Notes

Reaction equation

HRID 1984160 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:18]([N:22]1[C:26]([CH:27]=O)=[CH:25][C:24]([CH2:29][CH:30]([CH3:32])[CH3:31])=[N:23]1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([N:22]1[C:26]([CH2:27][NH:17][CH2:16][CH2:15][N:12]2[CH2:11][CH2:10][N:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[CH2:14][CH2:13]2)=[CH:25][C:24]([CH2:29][CH:30]([CH3:32])[CH3:31])=[N:23]1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 12561082-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamineHCID 866110582-t-Butyl-5-iso-butylpyrazole-3-carbaldehyde

Product 1

HCID 160386412-t-Butyl-5-iso-butyl-3-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 29.7%

Procedure

Compound 41 was prepared using the same method as that of Example 1 except that 4-(4-methoxyphenyl)piperazin-1-ylethylamine and 2-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-82b58f08b3df4139af434eddeb399e67
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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