2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamine → 5-(Furan-2-yl)-3-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl pyrazole

HRID 1984162Notes

Reaction equation

HRID 1984162 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:18]1([N:24]2[C:28]([C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[CH:27][C:26]([CH:34]=O)=[N:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[O:30]1[CH:31]=[CH:32][CH:33]=[C:29]1[C:28]1[N:24]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:25]=[C:26]([CH2:34][NH:17][CH2:16][CH2:15][N:12]2[CH2:11][CH2:10][N:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[CH2:14][CH2:13]2)[CH:27]=1

Participants

3

Reactant 2

HCID 12561082-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamineHCID 592816101-Phenyl-5-(2-furyl)pyrazole-3-carbaldehyde

Product 1

HCID 160387035-(Furan-2-yl)-3-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl pyrazoleYield 74.1%

Procedure

Compound 43 was prepared using the same method as that of Example 1 except that 4-(4-methoxyphenyl)piperazin-1-ylethylamine and 1-phenyl-5-(2-furyl)pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-cc557020ed904bb787f53e0ea177820f
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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