4-(4-Nitrophenyl)piperazin-1-ylethylamine → 1,5-Diphenyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984172Notes

Reaction equation

HRID 1984172 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][NH2:18])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:19]1([N:25]2[C:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:28][C:27]([CH:36]=O)=[N:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:19]1([N:25]2[C:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:28][C:27]([CH2:36][NH:18][CH2:17][CH2:16][N:13]3[CH2:12][CH2:11][N:10]([C:7]4[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=4)[CH2:15][CH2:14]3)=[N:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 289138874-(4-Nitrophenyl)piperazin-1-ylethylamineHCID 534070841,5-Diphenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160387841,5-Diphenyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 68.5%

Procedure

Compound 55 was prepared using the same method as that of Example 1 except that 4-(4-nitrophenyl)piperazin-1-ylethylamine and 1,5-diphenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-165aaac0a66841cd9cddaacdf56209f8
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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