2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-methyl-1-phenylpyrazole

HRID 1984175Notes

Reaction equation

HRID 1984175 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[CH3:17][C:18]1[N:22]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:21]=[C:20]([CH:29]=O)[CH:19]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][CH2:29][C:20]2[CH:19]=[C:18]([CH3:17])[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:21]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 141352365-Methyl-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160389273-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-methyl-1-phenylpyrazoleYield 87.4%

Procedure

Compound 61 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-methyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-d5a757d968a24a50a0d60c72f8c5ae38
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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